Investigators explored liver TET1 in metabolic dysfunction-associated steatotic liver disease (MASLD) progression. Depleting TET1 using two different strategies substantially alleviated MASLD progression. [EMBO Molecular Medicine] Full...

[Journal for ImmunoTherapy of Cancer] Researchers evaluated the safety and antitumor efficacy of locally administered interleukin 12 (IL-12) using a clinically translatable cytokine delivery platform to identify Tpex recruitment capabilities at tolerable cytokine doses.

[Journal for ImmunoTherapy of Cancer] To identify the characteristics of recombinant adenovirus-SIRPα/Siglec-10, investigators conducted CCK8 assay, quantitative PCR, western blot, competitive binding assay, in vitro cytotoxicity assay, ELISA and phagocytosis assay.

[Cancer Immunology Research] Investigators explored the potential of memory-like natural killer cells and Fc-enhanced CD19-ADCC in combination with tyrosine kinase inhibitor directed against kinase-driven leukemia models, including patient-derived xenografted Philadelphia-like acute lymphoblastic leukemia (Ph-like ALL).

[Cancer Immunology Research] Investigators synthetized mRNA encoding gasdermin E (GSDME) encapsulated by lipid nanoparticles (LNP-Gsdme). In situ delivery of LNP-Gsdme through intratumoral injection suppressed tumor growth, boosted monocyte infiltration and activated CD8+T cells.

[Journal of Clinical Investigation] Researchers investigated the cellular and molecular factors required to facilitate the generation of an ILC1-like CD49a+NK cell population within the liver metastasis environment of colorectal cancer.

[Nature Communications] Investigators demonstrated that trained monocytes preferentially employed lactate over glucose as a tricarboxylic acid cycle substrate, and lactate metabolism was required for trained immune cell responses to bacterial and fungal infection.

[Astrazeneca] AstraZeneca’s Imfinzi in combination with gemcitabine and cisplatin as neoadjuvant treatment, followed by Imfinzi as adjuvant monotherapy after radical cystectomy has been approved in the US for the treatment of adult patients with muscle-invasive bladder cancer.

[Trends In Cancer] The authors discuss the evolutionary dynamics of the immune landscape, particularly that of liver-resident Kupffer cells, TREM2+, and SPP1+ macrophages with an active role during liver disease progression, which eventually fuel hepatocarcinogenesis.

[Nature] Investigators reported on a unique regeneration mechanism involving unconventional RPB5 prefoldin interactor 1 (URI1), which exclusively colocalized with, bound to and activated glutamine synthase in pericentral hepatocytes.

[Molecular Cancer] Scientists investigated the functional role of circular RNA circDCUN1D4 in HCC progression and its potential therapeutic implications.

[Discovery Oncology] The authors provides a comprehensive summary of literature evidence for the independent prognostic significance of cytokine biomarkers in HCC patients receiving different therapies.